rel-5-[(1R,3aS,4S,6aS)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole
fargesin
CAS: 31008-19-2
Molecular Formula: C21H22O6
rel-5-[(1R,3aS,4S,6aS)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole - Names and Identifiers
rel-5-[(1R,3aS,4S,6aS)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole - Physico-chemical Properties
| Molecular Formula | C21H22O6 |
| Molar Mass | 370.4 |
| Density | 1.265±0.06 g/cm3(Predicted) |
| Melting Point | 132.0 to 136.0 °C |
| Boling Point | 506.4±50.0 °C(Predicted) |
| Flash Point | 208.923°C |
| Solubility | Soluble in benzene, DMSO and other solvents. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Colorless crystal |
| Storage Condition | 2-8°C |
| Refractive Index | 1.58 |
| MDL | MFCD28989184 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Xinyi, Wangchun Magnolia bud. |
| In vitro study | Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-ĸB. Fargesin as a potential β₁ adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. |
| In vivo study | Fargesin has antihypertensive effect in 2K1C hypertensive rats via inhibiting oxidative stress and promoting NO release. |
rel-5-[(1R,3aS,4S,6aS)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole - Reference
| Reference Show more | 1. Guang Yang, Xin Zhao, Guorong Fan,A modification on the vector cosine algorithm of Similarity Analysis for improved discriminative capacity and its application to the quality control of Magnoliae Flos,Journal of Chromatography A,Volume 1518,2017,Pages 2. [IF=4.759] Guang Yang et al."A modification on the vector cosine algorithm of Similarity Analysis for improved discriminative capacity and its application to the quality control of Magnoliae Flos."J Chromatogr A. 2017 Oct;1518:34 |
rel-5-[(1R,3aS,4S,6aS)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole - Reference Information
| overview | magnolia vulgaris is derived from the buds of Wang Chunhua, a plant of the genus Magnoliaceae, Magnolia biondii Pamp, and is a commonly used clinical traditional Chinese medicine. The nature and taste are pungent and warm, and have the effects of spreading wind and cold and spreading the nose. Indications of nasal congestion, wind-cold headache, nasal deep, nasal turbidity and other symptoms. The composition of Xinyi is complex. The Dictionary of Traditional Chinese Medicine records 78 components, which can be divided into water-soluble components, fat-soluble components and volatile oil components. According to recent research reports, the chloroform in the alcohol extract of Xinyi was separated by column chromatography, and a monomer component was obtained, which was analyzed by spectroscopy. Modern studies have confirmed that Magnolia has a wide range of pharmacological effects such as anti-histamine, anti-inflammatory, local convergence, central inhibition, anti-pathogenic microorganisms, and lowering blood pressure. Pharmacological experiments have confirmed that the main material basis for the anti-allergic pharmacological effect of Magnolia is volatile oil components. |
| biological activity | Fargesin is an active neo-lignan isolated from magnolia plants, which has anti-hypertensive and anti-inflammatory effects. |
| in vitro study | Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-branding B. Fargesin as a potential β adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. |
| in vivo study | Fargesin has antihypertensive effect in 2K1C hypertensive rats via inhibiting oxidative stress and promoting NO release. |
| chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Xinyi, wangchun magnolia buds. |
| use | magnolipids have antihypertensive and anti-inflammatory effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: promoting blood circulation and relieving pain, anti-inflammatory, and treating irregular menstruation. |
Last Update：2024-04-09 21:04:16
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Product Name: Fargesin Visit Supplier Webpage Request for quotationCAS: 31008-19-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: demethoxyaschantin Visit Supplier Webpage Request for quotationCAS: 31008-19-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Fargesin Visit Supplier Webpage Request for quotationCAS: 31008-19-2
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
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